This course focuses on the molecular, cellular and genetic aspects of normal and abnormal development, including cancer. In the first module (one third of the course), we make use of a variety of model systems such as the zebrafish, mouse and Drosophila to address molecular events underlying the development of body form, specific organs and tissues. We also explore later phases in the life cycle including maintenance of adult tissues (stem cells) and ageing. In the second module (the last two thirds of the course) we address
the fundamental mechanisms that cancer cells exploit to affect their growth and invasive properties. The molecular genetics of some cancers such as melanoma and colorectal cancers and the role of the immune system in cancer recognition will also be discussed. The links between developmental and cancer pathways are examined.
This course will interest a wide-range of students who want to know more about the molecular and cellular biology of development and disease with some perspectives about how this knowledge can lead to a clinical translation. The laboratories provide a unique opportunity to work with a wide-range of model organisms.
The course is part of:
- the BIOMED Cancer Biology and Therapeutics pathway (with MEDSCI319 and MEDSCI302)
- the BIOMED Reproduction and Development pathway (with MEDSCI312 and MESCI313)
- the BIOSCI Biochemistry and Cell Biology pathway ( as an option with BIOSCI350 and BIOSCI353)
- could be an elective in the BIOSCI Genetics pathway ( as an option with BIOSCI351 and BIOSCI355)